1P3: a) Application of the aldol condensation for the synthesis of diaryl-3-hydroxy-2,3,3a,10a-tetrahydrobenzo[b]cycylopenta[e]azepine-4,10(1H,5H)-diones

Kunick et al.¹⁶ synthesized diastereoselective diaryl-3-hydroxy-2,3,3a,10a-tetrahydrobenzo[b]cycylopenta[e]azepine-4,10(1H,5H)-diones is described employing a tandem Michael-aldol addition as key step (Scheme 1). The novel compounds exhibit antiproliferative activity in a panel of in vitro cultivated cancer cell lines.

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16.  C. Kunick, C. Bleeker, C. Prühs, C. S. Totzke, M. H. J. Kubbutat, and A. Link, Bioorg. Med. Chem. Lett., 2006, 16, 2148.


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