1P16: n) 1, 3-Iminoketones as new synthons for the stereocontrolled preparation of useful carbapenem intermediates

Alcaide et al.⁴⁸ has been developed an efficient, totally stereoselective two-step synthesis of cis- and trans-carbapenem intermediates (72-73) based upon the reaction of N-methoxycarbonylmethyl 1, 3-iminoketones (70) with benzyloxyacetyl chloride followed by a stereocontrolled intramolecular aldol-type condensationas shown in scheme 16.

____________________
48. B. Alcaide, J. Pẻrez-Castells, B. Sànchez-Vigo, and M. A. Sierra, Bioorg. Med. Chem. Lett., 1993, 3, 2369.
Next Page