M. Ghate et al.64
treated 4-(Bromomethyl) coumarins (145)
with vanillins, (146) give the
corresponding ethers (147), which underwent Knovenagel condensation with ethyl cyanoacetate
resulting in the formation of ethers (149)
contain an active methylene group and the ortho carbonyl group. Ethers (149), when refluxed in alcoholic
potassium carbonate underwent an intramolecular aldol reaction leading to the
formation of 4-(7’-methoxy 2’-benzo[b]furanyl)coumarins (150) and the aryloxymethyl Coumarin (148) with p-formyl group were found to
be most active as shown in scheme 26.
______________________
64. M. Ghate, D.
Manohar, V. Kulkarni, R. Shobha, and S. Y. Kattimani, Eur. J. Med. Chem., 2003, 38, 297.
Next Page
Next Page